EuResist in Africa: the EDCTP ENEAA project
EuResist has been supporting partner of the EDCTP networking action:
"Integrated training activities and IT infrastructures to improve capacities in eastern African area: European Network in Eastern African Area – ENEAA project" (EDCTP JP.2009.10800.002).
to conduct integrated training activities in order to improve expertise and Good Clinical Practice for surveillance and management of drug resistance
to upgrade on-site IT infrastructure and to conduct integrated training activities in order to improve IT data management
to analyse viral sequences from African patients and retrain the EuResist predictive system on African data
More than 950 sequences were generated from HIV patients at involved sites and analysed. Several papers have been published or submitted.
A strategy, "the split procedure", was developed and evaluated where all steps of GRT except sequencing is performed locally. A poster on these results was presented at the 6th EDCTP Forum, October 2011, Addis Ababa.
To expand the EuResist database to African context, sequences were generated from patients at baseline and therapy failure. Only limited transmitted drug resistance was identified. Results have been presented at the 5th EDCTP Forum October 2009, Arusha, Tanzania.
Trainees from the African countries were educated in GRT, database-management, IT-tools and statistics at three workshops:
- 1st training course on HIV drug resistance, 21st–25th February 2011, KEMRI
- 2nd training course on HIV drug resistance, 20th–22nd February 2012, KEMRI
- Training course on Database Management, IT-tools & basics of Statistics, 14-16th November 2011, MUHAS, Dar es Salaam
More than 25 trainees from participating centres and other Ethiopian and Tanzanian sites, Nigeria, Uganda and Zambia from non-ITAFR institutions participated.
Web tutorials available at this site: data management, HIV drug resistance
Capacity building and north-south collaboration
A stable collaboration among the partners has been settled which is continuing after the project end. Senior researchers from Muhumbili Hospital and from Addis Ababa University Hospital received high level education at KI in years 2013 and 2015, respectively. Two further students are registrated at KI as PhD students. Frequent exchanges occurred among Area Vasta Grosseto and World Friends Nairobi.Resistance data collection is ongoing with KI lab genotyping samples from Muhumbili Hospital and from Addis Ababa University Hospital and providing training in the lab. At the end of 2015 around 950 sequences have been analysed.
Study visits and conferences
Trainees have visited University of Siena and KI for further education and training in GRT and management of database/IT-tools (Dr Fikrie, Dr Worku, Dr Mugusi). Dr Fikrie and Dr Worku have spent around 9 months at KI also participitating in seminars and oral presentations.Trainees and senior partners from Africa were specially invited to the international Arevir-meeting where oral presentations were given.
A local version of the EuResist database, the EuResist Satellite database, was developed in order to facilitate the introduction of HIV treatment and resistance data from remote settings and local handling of data. The EuResist Satellite db has been installed in World Friends Hospital in Nairobi and education has been given. The EuResist Satellite db is freely available for anyone through the EuResist web-page.
A local version of InfCare HIV, applicable for Africa, was developed by Tanzanian senior partners and personnel from KI. Local education has been given 4 times.
Duration: 26/05/10 – 26/05/13
EDCTP Funding: 202.908,00 EUR
Prof. Anders Sonnerborg
Addis Ababa University, Ethiopia (G. Aderaye, D. Fekade)-
Muhumbili hospital, Dar-es-Salaam, Tanzania (F. Mugusi, M. Bakari)
World Friends Hospital, Nairobi, Kenya (G. F. Morino, N. Washington, M. Mwau)
- Area Vasta Toscana sud-est, Grosseto Hospital, Italy (M. Toti, M. Zazzi)
Co-funding and support from: EuResist Network (F. Incardona)