A European multidisciplinary network for the fight of HIV drug resistance
The project EuCARE, coordinated by EuResist Network GEIE, is short-listed for funding, among 11 Horizon Europe research projects on coronavirus variants.
On 22 July 2021, the EC announced that 11 projects were short-listed for funding, with total funding of €120 million. The 11 projects involve 312 research teams from 40 countries in Europe and beyond.
The project European Cohorts of Patients and Schools to Advance Response to Epidemics (EuCARE) gathers a comprehensive multidisciplinary team of clinicians, virologists, epidemiologists, statisticians and top experts in artificial intelligence to unveil the impact of SARS-CoV-2 variants on key sectors of public health.
To ensure a suitable representativeness of the different variants, vaccines and preventive measures, EuCARE has secured the appropriate cohorts from diverse geographic areas including European countries, Kenya, Mexico, Russia and Vietnam, and will consolidate or expand interactions with other cohorts. To deal with complex interactions among many variables, including large dimensional parameters, EuCARE harnesses the power of artificial intelligence to define the role of viral variants and inform clinical guidelines and prevention measures.
In the longer-term, EuCARE is committed to maintain active cooperation beyond the duration of the project. The solid IT and ethics infrastructure and the harmonised research procedures will make the cohort and laboratory network rapidly available to tackle newly emerging infectious diseases, thus contributing to pandemic preparedness on a global scale.
22nd July 2021 - the EC announced that 11 projects were short-listed for funding, with total funding of €120 million. The 11 projects involve 312 research teams from 40 countries in Europe and beyond.
Webinar "COVID-19 and variants: is it possible to re-open the schools?"
1st April 2021 - Held with success the webinar sponsored by EuResist Network, on the role of schools as centers for spread of the infection, the necessary containment measures and the costs of closure, in view of the new variants.
Over 850 distinct participants to the event and > 200 views of the registration
A PhD fellowship on Integrated models for HIV management has been funded by the EuResist Network at the PhD programme in Data Science of Sapienza University of Rome.
At Jan 2020 the number of INSTI containing therapies in the EIDB is >38000 and the number of TCEs is >5700
10 years of EURESISTANCE!
2009-2019: EuResist turns ten years old!
CARE HIV-TB-HCV: EU-Russia cooperation results
Online conference - June 15 2021, 9:00 – 16:00 CEST
The online meeting organised by the CARE Consortium had the objective to present and discuss outcomes and findings from CARE Common Action and other projects and initiatives in the frame of recent collaborative research in the WHO European Region.
It has seen the participation of CARE, ARREST-TB, CARE External Scientific Advisory Board, CARE External Ethics Review Board, Russian experts, NDPHS, Russian Ministry of Health, Russian Ministry of Science and Higher Education, EC, EU Delegation to the Russian Federation.
Download the Programme.
Webinar "COVID-19 and variants: is it possible to re-open the schools?"
1st April 2021 https://vimeo.com/event/832587
The marginal role of schools as a center for spreading the infection, when the necessary containment measures are adopted, is now demonstrated by most of the scientific literature. However, doubts remain in society and in the political world, especially as regards high schools and relatively to the spread of viral variants.
On the contrary, the costs of closure are not yet fully known and are still likely to be underestimated.
The webinar sponsored by EuResist Network will support the scientific discussion on these themes while involving both the civil society and the political institutions.
With the participation of scientists as Antonella D'arminio Monforte, Sara Gandini, Daniele Novara, of associations as Save the Children, AcrionAid, ForumDD, of members of the Italian Parliament and of the Minister for Equal Opportunities and the Family Elena Bonetti.
Download the programme
Relevant research results from the CARE project
The CARE TB diagnostics group has been looking into potential novel biomarkers of successful treatment of multidrug-resistant tuberculosis. With the support of Linear Mixed Models to analyse the change of metabolites in response to TB treatment in cohorts of patients from Russia and Lithuania, we identified and further evaluated at least 2 candidate urine biomarkers of response to treatment.
The CARE TB treatment management group has been progressing towards developing a Geno2Pheno TB tool for prediction of drug-resistance profiles of Mycobacterium tuberculosis (Mtb) from whole genome sequencing (WGS) data. We trained and evaluated a variety of RF-models on different genetic features for 9 important drugs using a set of up to 2,000 Mtb WGSs. The resulting models showed overall significantly improved performance compared to a state-of-the-art mutation catalogue, including both known resistance mediating and benign mutations.
The CARE HIV epidemiology and treatment resistance group has achieved important scientific progress in the evaluation of drug resistance to integrase strand inhibitors (INSTI). A new consensus A6 sequence has been created and also a full recombinant A6 viruse has been created which is now being tested against different drugs. A high-throughput sequencing assay for HIV-1 A6 strains has been established and validated on Swedish, German and Russian samples. The sub-subtype A6 has been analyzed for its in vitro phenotypic susceptibility to INSTIs and it showed to be as susceptible as the reference subtype B to INSTIs, including dolutegravir, bictegravir, cabotegravir.
Furthermore, the CARE HIV/HCV and host genomics group has enrolled an extensive prospective cohort of over 6500 people with HIV and HIV/HCV coinfection in Georgia, Russia and Ukraine. Detailed clinical and demographical data have been collected from the region of the world where we have little data so far. An HIV cascade of care constructed for this cohort showed that the target of 90% PLHIV on ART was achieved in Georgia and Ukraine but not in Russia, and the target of 90% on those on ART having viral suppression was achieved only in Georgia.
Held with success the conference on “Joint efforts against infectious diseases: HIV, TB, HCV”
Moscow, 27th January 2020
Held with success the high level conference in Moscow at the presence of the EU ambassador in Russia Mr Ederer, of the First Deputy Minister of the Ministry of Science and Higher Education of the Russian Federation Mr Trubnikov, and of the high representative of the Ministry of Health of the Russian Federation Mr Kostennikov,
The CARE and the ARREST-TB projects presented their interim results and fuelled a lively scientific discussion in a cooperative atmosphere.
EuResist Network is accepted as member of the UN Global Compact!
EuResist Network joins the UN Global Compact, the world's largest corporate initiative based on CEO commitments to implement universal sustainability principles and to take steps to support UN goals. See the Italian participants.
The CARE project publishes its first results
In only ten months of activity the CARE partners created a solid ethics permissions, data and samples sharing infrastructure for a wide network of collaboration against HIV, TB and HCV. Already three papers have been published on HIV-1 resistance and epidemiology and one poster presented at EACS 2019!The CARE project receives funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 825673.
INTEGRATE at EACS 2019
The INTEGRATE project results have been presented at. EACS 2019, in Basel on November 6-9 2019, with an oral talk entitled "Prevalence of InSTI resistance and effectiveness of InSTI based regimens in HIV infected patients: results from a European cohort" (B. Brossetti et al.). The presentation will take place on Thursday, November 7th 2019 during the session "Basic and translational HIV biology" (14:00-16:00).
The project has been supported by an unrestricted grant from Gilead Sciences.
Data from over 103, 000 HIV patients in EIDB
PhD fellowship on HIV molecular epidemiology
A PhD fellowship on HIV molecular epidemiology has been funded by the EuResist Network at the PhD programme in Data Science of Sapienza University of Rome.
About EuResist Network
EuResist Network is an international non-profit partnership devoted to understanding and fighting the resistance to anti-HIV drugs.
Its approach is eminentely multidisciplinary and focused on exploiting the power of real world data at the benefit of the individual patient.
EuResist Network manages:
the EuResist Integrated Data Base (EIDB), among the largest available databases of HIV genotypes and clinical response to antiretroviral therapy, with more than 96.000 patients. The EIDB is open for research studies.
Reasearch projects on HIV and other infectious diseases.. EuResist Network is actively involved in front end research to combat HIV drug resistance and the spread of HIV and other infectious diseases. It coordinates and participates in several research projects, including EU funded projects.
Training activities on HIV drug resistance and data management. EuResist Network organises on-site and distant courses and offers training material on drug resistance and drug resistance data management.
The EuResist prediction engine, a data-driven system which predicts the response to combination drug therapy for a patient with a given viral genotype. The engine has an overall accuracy of around 77% which compares favourably with existing rules-based state-of-the-art systems such as HIVdb, ANRS, REGA.
The EuResist Satellite DB (EsaDB), a tool for management of HIV patients data running locally on a PC. ESaDB is provided for free.
On Feb 4th 2019, our great friend and EuResister Andrea De Luca lost his life in a horrible car accident, at the age of 55.
One year has passed and still we miss him with incredulity and sorrow.
Among many other projects, Andrea joined EuResist as a key leader soon after its launch, devoting his energy, commitment and capability to the success of the Network. He was an extra lively, smart, passionate, and positive person, always ready to help and take new tasks.
His loss is a huge loss for us, for his patients, for his beloved ones, for the international research community.
Ciao Andrea, we'll always miss you.
CARE (Common Action against HIV/TB/HCV across the Regions of Europe) aims at analysing and addressing the human immunodeficiency virus (HIV), tuberculosis (TB) and hepatitis C (HCV) epidemics across Europe and Russia, by establishing new networks and consolidating previous cooperative actions between the European Union and the Russian Federation.
Project coordinator F. Incardona (EuResist Network) Scientific coordinator J. Lundgren (CHIP/RegionH).
Funding received from the EU’s H2020 research and innovation programme under g.a N. 825673
The INTEGRATE project aims at building and maintaining a large, curated collection of virological and clinical data to increase scientific knowledge on resistance to integrase strand transfer inhibitors (InSTI) and on the most appropriate use of this class of antiretroviral agents.
EuResist Network organises the EuResist Mentor School (EMS) an innovative educational project finalised to train young physicians and biologists in dealing with structured data (databases).
The EMS 2018 has been successfully held in Cologne
EuResist Network participates in the pilot project for the realization of a System of Health Monitoring and Surveillance activities in the Autonomous Region of Kurdistan...
EucoHIV is an independent self-constituted study group aiming at increasing scientific knowledge on HIV coreceptor usage and its clinical significance, including...
The EuResist Network is open to new partners of proved or potential scientific value for expanding both database and scientific programme. Co-operation with developing countries with high rates of HIV infections is mostly welcome.
All the partners have one representative in the EuResist Network Scientific Board. The Board evaluates requests to access the EIDB for scientific studies. Partner's activities and data are protected by the data and authorship policy.